Pathology Services
We provide microscopic tissue evaluation and pathology report generation for both regulatory and investigative projects. Our reports are SEND-ready and we are eager to work with you on your next GLP or non-GLP study.
We focus on providing capable and experienced expertise across the early stage drug development spectrum from manufacturing through preclinical development into the clinic. This enables our clients to access high-level expertise on an on-demand basis, thereby avoiding the expensive, and often underutilised, need to retain a full-time employee.
WHAT IS A PATHOLOGIST?
A pathologist is a medical healthcare provider who examines bodies and body tissues. He or she is also responsible for performing lab tests. A pathologist helps other healthcare providers reach diagnoses and is an important member of the treatment team.
WHAT IS A PATHOLOGY REPORT?
. A pathology report is a document that contains the diagnosis determined by examining cells and tissues under a microscope.
. This report is created by a pathologist; who is a doctor who does the examination and writes the pathology report for Vetpath customers.
Our Pathology Capabilities
Our pathology capabilities are extensive and cover a wide range of experience.
- Regulatory Pathology
- Toxicologic pathology in all species
- Carcinogenicity: conventional and genetically modified animals
- Pathology Peer Review
- Small molecule and biologicals
- Tissue Cross Reactivity
- Ocular Pathology
- Ocular toxicology
- Ocular inflammation
- Surgical and implant modeling
- Ocular pharmacology and efficacy
- Diabetes, CNV, OIR, macular degeneration
- Genetic strains
- Retinal disease
- Otic Pathology
- Drug induced systemic and local otic toxicity
- Hair cell and inner ear
- Implants
- External ear efficacy and tolerability
- Otic trauma
- Immunohistochemistry
- GLP Tissue Cross Reactivity studies
- GLP and non GLP evaluation in research and toxicology studies
- Receptor binding by test article
- IHC expression on target cell populations
- Pharmacology and Animal models
- Wound healing and burn models
- Oncology
- Ocular and Otic
- Dermal
- Bone and cartilage
- Hematology and bone marrow
- Liver and NASH
- Metabolic diseases
- IHC
- Medical device
- Inhalation models
- Pathology peer review
- Neurologic models
- Custom or special modeling
ADDITIONAL VETPATH SERVICES:
Accelerate Your Drug Development with VetPath’s Disease Modeling Expertise
Animal models are crucial for translating scientific breakthroughs into novel therapeutics.
With 35 years experience, VetPath specializes in the histopathology of investigative cutting edge animal models in rodent, nonrodent and primate tissues. Our pathologist, Dr Carol Meschter, has extensive experience in creating, developing and optimizing animal models of new diseases. VetPath Consultants has prepared hundreds of IND enabling reports and FDA regulatory submissions. We also enjoy a close collaborative relationship with a first rate GLP histology preparation laboratory that features both FFPE and plastic preparation as well as routine and special stains and immunohistochemistry.
OUR EXPERTISE INCLUDES:
- Comprehensive Model Selections
- Diverse Therapeutic Areas
- Tailored Solutions
- Unparalleled Expertise
Dr. Carol Meschter is highly trained in histomorphometric techniques on validated systems to enable routine or specialty analysis designed to accurately measure product performance.
Connect with VetPath to learn how our expertise in preclinical research can guide your drug development journey and help you achieve your therapeutic goals!
Your Partner in Protein Therapeutic Discovery and Development
Protein therapeutic discovery and development involves identifying therapeutic protein candidates and then optimizing and validating them through a multi-step process.
Animal Models:
In Protein therapeutic discovery and development, efficacy measurements in animal models are critical to demonstrate proof of concept and ensure translatability to humans. Examples of approved therapeutic proteins would include insulin, growth hormone, humira, growth hormone, erythropoietin, humanized antiTAC, and monoclonal antibodies. For fifty years, monoclonal antibodies, enzymes and fusion proteins have revolutionized medicine and enabled the treatment of diseases such as cancer, autoimmune diseases and genetic defects. In addition to drug discovery, the development of protein-based therapies also focuses on improving protein stability, delivery and bioengineering to increase therapeutic efficacy. Protein therapeutic discovery involves identifying potential drug candidates using methods like phage display and computational modeling, followed by engineering and optimization to improve binding affinity, in vivo stability, and pharmacokinetics through techniques such as PEGylation and Fc fusion. Development entails extensive analytical testing, in vitro assays, and in vivo efficacy studies in animal models to ensure the therapeutic’s safety, efficacy, and translatability to humans before clinical trials.
GLP and Investigative Toxicology and Pathology
Rodent, Nonrodent and Primate Tissues Models:
With 30 years experience, VetPath specializes in the histopathology of GLP toxicology studes in rodent, nonrodent and primate tissues. We have prepared hundreds of IND enabling reports and FDA regulatory submissions. We have an excellent QAU, and have a validated histopathology data acquisition computer program. We also enjoy a close collaborative relationship with a first rate GLP histology preparation laboratory that features both FFPE and plastic preparation as well as routine and special stains and immunohistochemistry.
Histopathology: Antisense Oligonucleotides
We at VPC have considerable expertise in the evaluation of histopathology concerning Antisense Oligonucleotides in safety and efficacy studies in laboratory animals.
An Antisense Oligonucleotide (ASO) is a short, synthetic single strand of DNA or RNA designed to bind to specific messenger RNA (mRNA) to control protein production acting as a therapeutic by either degrading the mRNA or altering its processing (splicing) to prevent disease-causing proteins or restore functional ones, a method used in treatments for genetic disorders like SMA or ATTR.
THERE ARE NUMEROUS AREAS OF THERAPEUTIC INDICATIONS INCLUDING:
ALS (Lou Gehrig’s Disease)
Huntington’s Disease
Alzheimer’s Disease
Facioscapulohumeral Muscular Dystrophy (FSHD)
Parkinson’s Disease
Spinocerebellar Ataxias (SCAs)
Tauopathies, and Synucleinopathies.
For histopathology assessment and support of research and toxicology tissues in animal studies, please contact us at VetPath Consultants.
Contact VetPath to discuss a scientific study program for your Pathology Studies and Services.
Phone: (571) 442-0372 • Contact Us